The efficacy of Tc-99m sestamibi for sentinel node mapping in breast carcinomas: comparison with Tc-99m antimony sulphide colloid.

نویسندگان

  • Ramin Sadeghi
  • Seyed Rasoul Zakavi
  • Mohammad Naser Forghani
  • Kamran Aryana
  • Vahid Reza Dabbagh Kakhki
  • Narjes Khatoon Ayati
  • Fatemeh Homaee Shandiz
  • Mohammad Reza Ghavamnasiri
  • Mohammed Keshtgar
چکیده

BACKGROUND To study the value of periareolar intra-dermal injection of Tc-99m sestamibi (MIBI) for sentinel node mapping in breast carcinoma. MATERIAL AND METHODS Fifty patients with early-stage breast cancer were included in our study. 17.5 MBq Tc-99m-MIBI was injected intradermally to 25 patients and the remainders were injected with the same dose of Tc-99m-antimony sulphide colloid. Anterior and lateral static images were taken at 2 minutes. If sentinel lymph node was not detected, delayed imaging by up to 180 minutes was carried out. The patients were operated on 2-4 hours post-injection. Sentinel lymph node biopsy was performed by the aid of gamma probe and blue dye during surgery. RESULTS In the Tc-99m-MIBI group, 23 patients had lymph nodes on scintigraphy images, and sentinel nodes were detected during surgery in all 23 patients. In the Tc-99m-antimony sulphide colloid group, 24 patients had lymph nodes on scintigraphy images, and sentinel nodes were identified during surgery in 24 patients. CONCLUSIONS We concluded that 99mTc-MIBI is a suitable radiopharmaceutical for sentinel node detection.

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عنوان ژورنال:
  • Nuclear medicine review. Central & Eastern Europe

دوره 13 1  شماره 

صفحات  -

تاریخ انتشار 2010